Fluoride Burden of Aluminum Plant Workers

Fluoride (F), a powerful oxidizing agent, is used in a variety of industries in China. Health problems among industrial workers due to F poisoning are on the rise. Long-term F exposure, together with varieties of relevant factors, leads to high F burden [blood fluoride (BF), urinary fluoride (UF)], which can finally result in F bone injury (1). As F burden is the major cause of F bone injury, to prevent the F bone injury, we have to control the F burden to a moderate level. The purpose of the present study was to examine the F burden and relevant factors of aluminum plant workers, and provide the basis for the early prevention of F bone injury. Overall, 300 subjects, 20 to 50 of age, were randomly selected from workshops of an aluminum plant, who have been working in their present position for 5 years or longer. We conducted a face-to-face questionnaire for the 300 subjects. After finishing the questionnaire, only 279 subjects were included in our study. The participating subjects signed informed consent forms. Blood samples were collected from a brachial vein within a few minutes after the end of the shift. Urine samples were collected as follows: just before the afternoon half-shift, the workers were asked to empty their bladders; then a sample of urine was collected at the end of the shift, just after blood drawing. Blood and urine samples were kept refrigerated until analysis. Air samples were collected from 6 different points in each workshop 16 times per day, for two consecutive days. The levels of BF and UF were determined by fluoride ion-selective electrode method. Levels of AF were determined by filter sampling and fluoride ion-selective electrode method (2, 3). and had been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. Statistical analyses were performed using SPSS 16.0 statistical software. The highest AF was observed in aluminum elec-trolytic workshop (2.31±1.01mg/m3), followed by aluminum pole workshop (0.36±0.10mg/m3), the lowest observed in the office area (0.11±0.09mg/m3). The differences among the three workshops were significant (P<0.01).Means and standard deviations of BF and UF levels are presented in Table1, for workers classified by different factors. Results showed that BF of aluminum electrolytic workers were significantly higher than that of aluminum pole workers and that of office workers (P<0.01); BF of aluminum pole workers were significantly higher than that of …